BACKGROUND AND PURPOSE The sigma‐1 (σ1) receptor is a ligand‐regulated molecular
chaperone that has been involved in pain, but there is limited understanding of the actions …

Abstract Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …

There is a critical need for new analgesics acting through new mechanisms of action, which
could increase the efficacy with respect to existing therapies and reduce their unwanted …

We have previously shown that the selective sigma‐1 receptor (σ1R) antagonist S1 RA (E‐
52862) inhibits neuropathic pain and activity‐induced spinal sensitization in various pre …

E-52862 is a selective σ1R antagonist currently undergoing phase II clinical trials for
neuropathic pain and represents a potential first-in-class analgesic. Here, we investigated …

Sigma-1 receptor (σ1R) is expressed in key CNS areas involved in nociceptive processing
but only limited information is available about its functional role. In the present study we …

Abstract Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous
recombination, and separate pharmacological studies in wild type (WT) mice were done to …

Introduction: The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone that
interacts with other proteins, including NMDA and opioid receptors, to modulate their activity …

There is a critical need for new analgesics acting through new mechanisms of action, which
could increase the efficacy respect to existing therapies and/or reduce their unwanted …

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without
the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of …