Integrons: mobilizable platforms that promote genetic diversity in bacteria
Integrons facilitate the capture of potentially adaptive exogenous genetic material by their
host genomes. It is now clear that integrons are not limited to the clinical contexts in which …
host genomes. It is now clear that integrons are not limited to the clinical contexts in which …
Integrons: natural tools for bacterial genome evolution
DA Rowe-Magnus, D Mazel - Current opinion in microbiology, 2001 - Elsevier
Integrons were first identified as the primary mechanism for antibiotic resistance gene
capture and dissemination among Gram-negative bacteria. More recently, their role in …
capture and dissemination among Gram-negative bacteria. More recently, their role in …
Integrons: past, present, and future
MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
The natural history of integrons
Integrons were first identified because of their central role in assembling and disseminating
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …
Integrons: agents of bacterial evolution
D Mazel - Nature Reviews Microbiology, 2006 - nature.com
Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …
Integrons: vehicles and pathways for horizontal dissemination in bacteria
S Domingues, GJ da Silva, KM Nielsen - Mobile genetic elements, 2012 - Taylor & Francis
Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …
integrons were initially described in human clinical isolates, they have now been identified …
The evolution of class 1 integrons and the rise of antibiotic resistance
Class 1 integrons are central players in the worldwide problem of antibiotic resistance,
because they can capture and express diverse resistance genes. In addition, they are often …
because they can capture and express diverse resistance genes. In addition, they are often …
The role of integrons in antibiotic resistance gene capture
DA Rowe-Magnus, D Mazel - International Journal of Medical Microbiology, 2002 - Elsevier
Although recently discovered, integrons have played a primordial role in the evolution of
bacterial genomes. They are best known as the genetic agents responsible for the capture …
bacterial genomes. They are best known as the genetic agents responsible for the capture …
The peril and promise of integrons: beyond antibiotic resistance
Integrons are bacterial genetic elements that can capture, rearrange, and express mobile
gene cassettes. They are best known for their role in disseminating antibiotic-resistance …
gene cassettes. They are best known for their role in disseminating antibiotic-resistance …
Class 1 integrons, gene cassettes, mobility, and epidemiology
AC Fluit, FJ Schmitz - European Journal of Clinical Microbiology and …, 1999 - Springer
Integrons are genetic elements that, although unable to move themselves, contain gene
cassettes that can be mobilized to other integrons or to secondary sites in the bacterial …
cassettes that can be mobilized to other integrons or to secondary sites in the bacterial …