Integrons: mobilizable platforms that promote genetic diversity in bacteria

Y Boucher, M Labbate, JE Koenig, HW Stokes - Trends in microbiology, 2007 - cell.com
Integrons facilitate the capture of potentially adaptive exogenous genetic material by their
host genomes. It is now clear that integrons are not limited to the clinical contexts in which …

Integrons: natural tools for bacterial genome evolution

DA Rowe-Magnus, D Mazel - Current opinion in microbiology, 2001 - Elsevier
Integrons were first identified as the primary mechanism for antibiotic resistance gene
capture and dissemination among Gram-negative bacteria. More recently, their role in …

Integrons: past, present, and future

MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

The natural history of integrons

TM Ghaly, MR Gillings, A Penesyan, Q Qi, V Rajabal… - Microorganisms, 2021 - mdpi.com
Integrons were first identified because of their central role in assembling and disseminating
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …

Integrons: agents of bacterial evolution

D Mazel - Nature Reviews Microbiology, 2006 - nature.com
Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …

Integrons: vehicles and pathways for horizontal dissemination in bacteria

S Domingues, GJ da Silva, KM Nielsen - Mobile genetic elements, 2012 - Taylor & Francis
Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …

The evolution of class 1 integrons and the rise of antibiotic resistance

M Gillings, Y Boucher, M Labbate, A Holmes… - Journal of …, 2008 - Am Soc Microbiol
Class 1 integrons are central players in the worldwide problem of antibiotic resistance,
because they can capture and express diverse resistance genes. In addition, they are often …

The role of integrons in antibiotic resistance gene capture

DA Rowe-Magnus, D Mazel - International Journal of Medical Microbiology, 2002 - Elsevier
Although recently discovered, integrons have played a primordial role in the evolution of
bacterial genomes. They are best known as the genetic agents responsible for the capture …

The peril and promise of integrons: beyond antibiotic resistance

TM Ghaly, JL Geoghegan, SG Tetu, MR Gillings - Trends in microbiology, 2020 - cell.com
Integrons are bacterial genetic elements that can capture, rearrange, and express mobile
gene cassettes. They are best known for their role in disseminating antibiotic-resistance …

Class 1 integrons, gene cassettes, mobility, and epidemiology

AC Fluit, FJ Schmitz - European Journal of Clinical Microbiology and …, 1999 - Springer
Integrons are genetic elements that, although unable to move themselves, contain gene
cassettes that can be mobilized to other integrons or to secondary sites in the bacterial …