NetworKIN: a resource for exploring cellular phosphorylation networks
Protein kinases control cellular responses by phosphorylating specific substrates. Recent
proteome-wide mapping of protein phosphorylation sites by mass spectrometry has …
proteome-wide mapping of protein phosphorylation sites by mass spectrometry has …
Uncovering phosphorylation-based specificities through functional interaction networks
Protein kinases are an important class of enzymes involved in the phosphorylation of their
targets, which regulate key cellular processes and are typically mediated by a specificity for …
targets, which regulate key cellular processes and are typically mediated by a specificity for …
Prediction of 492 human protein kinase substrate specificities
Background Complex intracellular signaling networks monitor diverse environmental inputs
to evoke appropriate and coordinated effector responses. Defective signal transduction …
to evoke appropriate and coordinated effector responses. Defective signal transduction …
[HTML][HTML] Recent advances in kinase signaling network profiling by mass spectrometry
Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …
study of global kinase signaling. The scientific community is continuously releasing …
PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database
CY Yang, CH Chang, YL Yu, TCE Lin, SA Lee… - …, 2008 - academic.oup.com
Motivation: To fully understand how a protein kinase regulates biological processes, it is
imperative to first identify its substrate (s) and interacting protein (s). However, of the 518 …
imperative to first identify its substrate (s) and interacting protein (s). However, of the 518 …
PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection
Protein phosphorylation is a major form of post-translational modification (PTM) that
regulates diverse cellular processes. In silico methods for phosphorylation site prediction …
regulates diverse cellular processes. In silico methods for phosphorylation site prediction …
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases
Protein kinases enable cellular information processing. Although numerous human
phosphorylation sites and their dynamics have been characterized, the evolutionary history …
phosphorylation sites and their dynamics have been characterized, the evolutionary history …
Systematic discovery of in vivo phosphorylation networks
Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
PhosphoNetworks: a database for human phosphorylation networks
Phosphorylation plays an important role in cellular signal transduction. Current
phosphorylation-related databases often focus on the phosphorylation sites, which are …
phosphorylation-related databases often focus on the phosphorylation sites, which are …
Systematic analysis of protein phosphorylation networks from phosphoproteomic data
In eukaryotes, hundreds of protein kinases (PKs) specifically and precisely modify
thousands of substrates at specific amino acid residues to faithfully orchestrate numerous …
thousands of substrates at specific amino acid residues to faithfully orchestrate numerous …