Inhibition of mTOR signaling enhances maturation of cardiomyocytes derived from human-induced pluripotent stem cells via p53-induced quiescence
Background: Current differentiation protocols to produce cardiomyocytes from human
induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte …
induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte …
The long and winding road of cardiomyocyte maturation
G Maroli, T Braun - Cardiovascular Research, 2021 - academic.oup.com
Abstract Knowledge about the molecular mechanisms regulating cardiomyocyte (CM)
proliferation and differentiation has increased exponentially in recent years. Such insights …
proliferation and differentiation has increased exponentially in recent years. Such insights …
Learn from your elders: developmental biology lessons to guide maturation of stem cell-derived cardiomyocytes
Human pluripotent stem cells (hPSCs) offer a multifaceted platform to study cardiac
developmental biology, understand disease mechanisms, and develop novel therapies …
developmental biology, understand disease mechanisms, and develop novel therapies …
Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Engineering adolescence: maturation of human pluripotent stem cell–derived cardiomyocytes
The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
S Chung, PP Dzeja, RS Faustino… - Nature clinical practice …, 2007 - nature.com
Cardiogenesis within embryos or associated with heart repair requires stem cell
differentiation into energetically competent, contracting cardiomyocytes. While it is widely …
differentiation into energetically competent, contracting cardiomyocytes. While it is widely …
Proteasome-dependent regulation of distinct metabolic states during long-term culture of human iPSC-derived cardiomyocytes
Rationale: The immature presentation of human induced pluripotent stem cell–derived
cardiomyocytes (iPSC-CMs) is currently a challenge for their application in disease …
cardiomyocytes (iPSC-CMs) is currently a challenge for their application in disease …
Mitochondria in control of cell fate
CDL Folmes, PP Dzeja, TJ Nelson, A Terzic - Circulation research, 2012 - Am Heart Assoc
genes and transcription factors, and promoting stem cell cardiac differentiation. 20–22 Such
cardiogenic effects appear to be concentration-dependent, as high levels of ROS can delay …
cardiogenic effects appear to be concentration-dependent, as high levels of ROS can delay …
Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
S Vučković, R Dinani, EE Nollet, DWD Kuster… - Stem cell research & …, 2022 - Springer
Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …
emerged as a powerful tool for disease modeling, though their immature nature currently …
Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?
CC Veerman, G Kosmidis, CL Mummery… - Stem cells and …, 2015 - liebertpub.com
Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …