The treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the
blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain …

High level of detrimental factors including reactive oxygen species (ROS) and inflammatory
cytokines accumulated in the infarct core and their erosion to salvageable penumbra are key …

Neuroinflammation has emerged as a major concern in ischemic stroke therapy because it
exacebates neurological dysfunction and suppresses neurological recovery after …

Oxidative stress induced by ischemia‐reperfusion causes severe secondary injury in stroke
patients. The blood‐brain barrier (BBB) and the challenges in targeting the stroke core …

As a ROS scavenger, resveratrol exerts a neuroprotective effect by polarizing the M1
microglia to the anti-inflammatory M2 phenotype for ischemic stroke treatment. However, the …

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological …

Background Ischemic stroke is an acute and severe neurological disease, and reperfusion is
an effective way to reverse brain damage after stroke. However, reperfusion causes …

Following ischemic stroke, brain‐resident activated microglia and peripherally infiltrated
inflammatory cells create a complicated and overactivated brain immune microenvironment …

Ischemic stroke is an acute and severe neurological disease, resulting in disability and
death. Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; …

Brain inflammation is regarded as one of the leading causes that aggravates secondary
brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high …