The bacterial cell wall has been a celebrated target for antibiotics and holds real promise for
the discovery of new antibacterial chemical matter. In addition to peptidoglycan, the walls of …

Wall teichoic acids are a major and integral component of the Gram-positive cell wall. These
structures are present across all species of Gram-positive bacteria and constitute roughly …

One of the major differences between Gram-negative and Gram-positive organisms is the
presence or absence of an outer membrane (Figure 1). In Gram-negative organisms, the …

Wall teichoic acids (WTAs) are anionic polymers that decorate the cell walls of many Gram-
positive bacteria. These structures are essential for survival or virulence in many organisms …

An extensive literature has established that the synthesis of wall teichoic acid in Bacillus
subtilis is essential for cell viability. Paradoxically, we have recently shown that wall teichoic …

The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

Both Gram-positive and Gram-negative bacteria contain bactoprenol-dependent
biosynthetic pathways expressing non-essential cell surface polysaccharides that function …

Highlights•Teichoic acids are conserved glycopolymers found in Gram-positive cell
envelopes.•LTA biosynthetic genes are essential and good targets for traditional …

Resistance to every family of clinically used antibiotics has emerged, and there is a pressing
need to explore unique antibacterial targets. Wall teichoic acids (WTAs) are anionic …

An extensive study of teichoic acid biosynthesis in the model organism Bacillus subtilis has
established teichoic acid polymers as essential components of the gram-positive cell wall …