The transcription factor grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm
(NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice …

Background: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a
critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN …

Abstract Grainyhead-like 3 (Grhl3) is a transcription factor involved in epithelial
morphogenesis. In the present study, we evaluated the developmental role of Grhl3 in …

Abstract Epithelial-mesenchymal transition (EMT), a biological process by which polarized
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …

The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial
development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning …

Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all
cancer-related deaths in children. Novel therapeutic strategies are therefore urgently …

Abstract Background The transcription factor Grainyhead‐like 3 (GRHL3) has multiple roles
in a variety of tissues during development including epithelial patterning and actin …

The partner of activated epidermal growth factor receptor (EGFR), growth factor receptor
bound protein-7 (Grb7), a functionally multidomain adaptor protein, has been demonstrated …

Background & Aims Esophageal squamous cell carcinoma (ESCC) is an aggressive
malignancy with a poor long-term prognosis. The molecular mechanisms underlying the …

Background Increased apposition of the frontal and parietal bones of the skull during
embryogenesis may be a risk factor for the subsequent development of premature skull …