There is growing evidence that adenosine is a potent inhibitor of neuronal activity in the
central (CNS) and peripheral nervous systems. Four major subtypes of adenosine receptors …

Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …

1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

Electrophysiological recordings in rat brain slices have been used to study the actions of
adenosine on striatal neurons and striatal excitatory amino acid neurotransmission …

Monoclonal antibodies were generated against the adenosine A1 receptor (A1R) purified
from rat brain. In immunoblot analyses of purified or partially purified A1R preparations from …

Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1
and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and …