BACKGROUND. The secreted frizzled‐related protein 1 gene (SFRP1) encodes a Wnt/β‐
catenin signaling antagonist and frequently is inactivated by promoter methylation in many …

Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in human cancers.
The secreted frizzled‐related proteins (SFRPs) function as negative regulators of Wnt …

Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular
carcinoma (HCC). The secreted frizzled‐related proteins (SFRPs) function as negative …

Introduction The secreted frizzled-related protein 1 (SFRP1) gene, as a Wnt signaling
modulator, is frequently inactivated by promoter methylation in many tumors including …

Background Hepatocellular carcinoma (HCC) is one of the most common cancers in the
world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene …

Abstract Background Activation of the Wnt signaling pathway is frequently observed in
hepatocellular carcinoma (HCC), though mutation of three of its components, CTNNB1 …

The Wnt pathway is a key regulator of embryonic development and stem cells, and its
aberrant activation is associated with human malignancies, most notably hepatocellular …

Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at
8p11. 2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by …

AIM: To investigate the functions of promoter hyper-methylation of secreted frizzled-related
proteins (sFRPs) genes in colorectal tumorigenesis and progression. METHODS: The …

AIM: To determine the methylation status and aberrant expression of some secreted frizzled-
related protein (SFRP) genes in pancreatic cancer and explore their role in pancreatic …