Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases
that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety …

Mono ADP-ribosylation is a common characteristic of bacterial toxins resulting to aberrant
activation or inactivation of target proteins. The C3 exoenzyme of Clostridium botulinum …

The C3-like ADP-ribosyltransferases exhibit a very confined substrate specificity compared
with other Rho-modifying bacterial toxins; they selectively modify the RhoA,-B, and-C …

Clostridium botulinum C3 is the prototype of C3-like ADP-ribosyltransferases that selectively
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …

ADP-ribosyltransferase C3 is an exoenzyme produced by several strains of Clostridium
botulinum. It was serendipitously detected during screening for high producer strains of C …

RhoA,-B, and-C are ADP-ribosylated by Clostridium botulinum exoenzyme C3 to induce
redistribution of the actin filaments in intact cells, a finding that has led to the notion that the …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …

The family of C3-like exoenzymes comprises seven bacterial ADP-ribosyltransferases of
different origin. The common hallmark of these exoenzymes is the selective N-ADP …

Clostridium botulinum C3 ADP-ribosyltransferase (botulinum C3 exoenzyme) is an
exoenzyme which is produced as a single polypeptide of about 23 kDa by Clostridium …

C3-like ADP-ribosyltransferases represent an expanding family of related exoenzymes,
which are produced by Clostridia and various Staphylococcus aureus strains. Here we …