Thermodynamic parameters for binding of some halogenated inhibitors of human protein kinase CK2

M Winiewska, M Makowska, P Maj… - Biochemical and …, 2015 - Elsevier
The interaction of human CK2α with a series of tetrabromobenzotriazole (TBBt) and
tetrabromobenzimidazole (TBBz) analogs, in which one of the bromine atoms proximal to …

Thermodynamics parameters for binding of halogenated benzotriazole inhibitors of human protein kinase CK2α

M Winiewska, K Kucińska, M Makowska… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The interaction of human CK2α (hCK2α) with nine halogenated benzotriazoles, TBBt and its
analogues representing all possible patterns of halogenation on the benzene ring of …

A competition between hydrophobic and electrostatic interactions in protein–ligand systems. Binding of heterogeneously halogenated benzotriazoles by the catalytic …

S Kasperowicz, E Marzec, AM Maciejewska… - IUBMB …, 2020 - Wiley Online Library
A series of chlorine‐substituted benzotriazole derivatives, representing all possible
substitution patterns of halogen atoms attached to the benzotriazole benzene ring, were …

Halogen Atoms in the Protein–Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human …

H Czapinska, M Winiewska-Szajewska… - The Journal of …, 2021 - ACS Publications
Binding of a family of brominated benzotriazoles to the catalytic subunit of human protein
kinase CK2 (hCK2α) was used as a model system to assess the contribution of halogen …

Relative role of halogen bonds and hydrophobic interactions in inhibition of human protein kinase CK2α by tetrabromobenzotriazole and some C (5)-substituted …

R Wasik, M Łebska, K Felczak… - The Journal of …, 2010 - ACS Publications
To examine the relative role of halogen bonding and hydrophobic interactions in the
inhibition of human CK2α by 4, 5, 6, 7-tetrabromobenzotriazole (TBBt), we have synthesized …

Thermodynamic contribution of iodine atom to the binding of heterogeneously polyhalogenated benzotriazoles by the catalytic subunit of human protein kinase CK2

E Marzec, J Poznański, D Paprocki - IUBMB life, 2020 - Wiley Online Library
A series of novel benzotriazole derivatives containing iodine atom (s) were synthesized. The
binding of these compounds to the catalytic subunit of human protein kinase CK2 was …

[HTML][HTML] Isomeric mono-, di-, and tri-bromobenzo-1H-triazoles as inhibitors of human protein kinase CK2α

R Wąsik, P Wińska, J Poznański, D Shugar - PloS one, 2012 - journals.plos.org
To further clarify the role of the individual bromine atoms of 4, 5, 6, 7-tetrabromotriazole
(TBBt), a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition …

[HTML][HTML] ITC-derived binding affinity may be biased due to titrant (nano)-aggregation. Binding of halogenated benzotriazoles to the catalytic domain of human protein …

M Winiewska, E Bugajska, J Poznański - PLoS One, 2017 - journals.plos.org
The binding of four bromobenzotriazoles to the catalytic subunit of human protein kinase
CK2 was assessed by two complementary methods: Microscale Thermophoresis (MST) and …

The halogenation of natural flavonoids, baicalein and chrysin, enhances their affinity to human protein kinase CK2

E Marzec, M Świtalska, M Winiewska‐Szajewska… - IUBMB …, 2020 - Wiley Online Library
A series of halogenated derivatives of natural flavonoids: baicalein and chrysin were
designed and investigated as possible ligands for the catalytic subunit of tumor‐associated …

Selectivity of 4, 5, 6, 7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources

P Zień, M Bretner, K Zastąpiło, R Szyszka… - … and biophysical research …, 2003 - Elsevier
Like the previously reported 4, 5, 6, 7-tetrabromobenzotriazole (TBBt), the structurally related
4, 5, 6, 7-tetrabromobenzimidazole (TBBz) is a selective ATP-competitive inhibitor of protein …