Background. Arachidonic acid metabolites known to affect platelet function also interfere
with tumor growth and metastases. The purpose of this study was to evaluate the anti …

Metastasis is a multistep phenomenon in which platelets appear to play an important role.
This study examined several compounds for their effects on experimental hepatic metastasis …

Human pancreatic cancer is an aggressive malignancy, with systemic metastases ultimately
accounting for its grave prognosis. Arachidonic acid metabolites known to affect platelet …

Arachidonic acid metabolites have been implicated in the development of hematogenous
tumor metastases. The purpose of this study was to determine the antimetastatic potential of …

Selective inhibition of eicosanoid synthesis seems to decrease carcinogenesis, however,
the effect on liver metastasis in pancreatic cancer is still unknown. Ductal pancreatic …

Selective inhibition of eicosanoid synthesis is thought to have effects on carcinogenesis in
lung and colon cancer. However, it is still unknown whether pancreatic cancer might also be …

Abstract Cyclooxygenase-2 (COX-2) inhibitors are being developed as chemopreventive
and anticancer agents. This study aimed to determine the biological effect of the COX-2 …

Previous studies suggest that antagonists of cyclooxygenases 1 and 2 (COX-1,-2) inhibit
angiogenesis in tumor xenografts, but the molecular mechanisms involved remain unclear …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2). It may reduce the risk of
cancer formation by affecting the metabolism of arachidonic acid (AA), which has been …

Abstract Purpose: Cyclooxygenase-2 (COX-2) inhibitors cause growth inhibition of human
hepatocellular carcinoma cells but it remains unclear whether this is both COX-2 dependent …