The mechanistic relationship of the inhibition of gap junctional intercellular communication
(GJIC) to other toxicological phenomena was explored using a recently developed method …

The normal development and health of all multicellular organisms, including the human
being, depend on the adaptive maintenance of the integrity of the genetic information (eg …

Results from short-term tests for carcinogens and our advanced knowledge on cellular and
molecular mechanisms of carcinogenesis strongly suggest that carcinogens do not induce …

During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …

Communication mechanisms [extra-, intra-, and gap junctional inter-cellular communication
(GJIC)] control, from the fertilized egg, through embryogenesis to maturity and aging …

The effects of five non-mutagenic carcinogens—Aroclor 1260, benzoyl peroxide (BP),
phenobarbital (PB), 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1, 1'-(2, 2, 2 …

Non-genotoxic carcinogens are thought to induce tumour formation by disturbing the
balance between cell growth and cell death. Gap junctions (GJ) contribute to the …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

Most, if not all, cancer cells have some dysfunction in gap-junction-mediated intercellular
communication, either because of defects in cell adhesion or inability to have functional gap …