Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging

N Rapoport, AM Kennedy, JE Shea… - Molecular …, 2010 - ACS Publications
Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cause of cancer death
in the United States, with a median survival time of only 3− 6 months for forty percent of …

[HTML][HTML] Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer

S Ng, AJ Healey, PC Sontum, S Kvåle, SH Torp… - Journal of Controlled …, 2022 - Elsevier
Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the
dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with …

Focused ultrasound-mediated drug delivery to pancreatic cancer in a mouse model

N Rapoport, A Payne, C Dillon, J Shea, C Scaife… - Journal of therapeutic …, 2013 - Springer
Background Many aspects of the mechanisms involved in ultrasound-mediated therapy
remain obscure. In particular, the relative roles of drug and ultrasound, the effect of the time …

Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal …

S Kotopoulis, E Stigen, M Popa, MM Safont… - Journal of Controlled …, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with
survival averaging only 3 months if untreated following diagnosis. A major limitation in …

Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma

J Castle, S Kotopoulis, F Forsberg - Drug Delivery Systems, 2020 - Springer
Pancreatic cancer is the third most common cancer diagnosed in the United States, with
more than 53,000 new cases in 2017. It is the fourth leading cause of cancer-related death …

Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer

H Nesbitt, Y Sheng, S Kamila, K Logan… - Journal of controlled …, 2018 - Elsevier
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …

Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy

N Rapoport, Z Gao, A Kennedy - Journal of the National Cancer …, 2007 - academic.oup.com
Background Drug delivery in polymeric micelles combined with tumor irradiation by
ultrasound results in effective drug targeting, but this technique requires prior tumor imaging …

Sono-promoted drug penetration and extracellular matrix modulation potentiate sonodynamic therapy of pancreatic ductal adenocarcinoma

H Xiao, X Li, B Li, Y Zhong, J Qin, Y Wang, S Han… - Acta Biomaterialia, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) exhibits difficult penetration of most drugs,
leading to a very poor therapeutic outcome with a quite low five-year survival rate. The …

Chronic effects of pulsed high intensity focused ultrasound aided delivery of gemcitabine in a mouse model of pancreatic cancer

TD Khokhlova, YN Wang, H Son, S Totten, S Whang… - Ultrasonics, 2023 - Elsevier
Pulsed high intensity focused ultrasound (pHIFU) is a non-invasive method that allows to
permeabilize pancreatic tumors through inertial cavitation and thereby increase the …

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

NY Rapoport, AM Kennedy, JE Shea, CL Scaife… - Journal of Controlled …, 2009 - Elsevier
The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …