Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging
N Rapoport, AM Kennedy, JE Shea… - Molecular …, 2010 - ACS Publications
Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cause of cancer death
in the United States, with a median survival time of only 3− 6 months for forty percent of …
in the United States, with a median survival time of only 3− 6 months for forty percent of …
[HTML][HTML] Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer
S Ng, AJ Healey, PC Sontum, S Kvåle, SH Torp… - Journal of Controlled …, 2022 - Elsevier
Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the
dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with …
dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with …
Focused ultrasound-mediated drug delivery to pancreatic cancer in a mouse model
Background Many aspects of the mechanisms involved in ultrasound-mediated therapy
remain obscure. In particular, the relative roles of drug and ultrasound, the effect of the time …
remain obscure. In particular, the relative roles of drug and ultrasound, the effect of the time …
Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal …
S Kotopoulis, E Stigen, M Popa, MM Safont… - Journal of Controlled …, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with
survival averaging only 3 months if untreated following diagnosis. A major limitation in …
survival averaging only 3 months if untreated following diagnosis. A major limitation in …
Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma
J Castle, S Kotopoulis, F Forsberg - Drug Delivery Systems, 2020 - Springer
Pancreatic cancer is the third most common cancer diagnosed in the United States, with
more than 53,000 new cases in 2017. It is the fourth leading cause of cancer-related death …
more than 53,000 new cases in 2017. It is the fourth leading cause of cancer-related death …
Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer
H Nesbitt, Y Sheng, S Kamila, K Logan… - Journal of controlled …, 2018 - Elsevier
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …
1%. With little improvement in survival rates observed in the past 40 years, there is a …
Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy
N Rapoport, Z Gao, A Kennedy - Journal of the National Cancer …, 2007 - academic.oup.com
Background Drug delivery in polymeric micelles combined with tumor irradiation by
ultrasound results in effective drug targeting, but this technique requires prior tumor imaging …
ultrasound results in effective drug targeting, but this technique requires prior tumor imaging …
Sono-promoted drug penetration and extracellular matrix modulation potentiate sonodynamic therapy of pancreatic ductal adenocarcinoma
H Xiao, X Li, B Li, Y Zhong, J Qin, Y Wang, S Han… - Acta Biomaterialia, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) exhibits difficult penetration of most drugs,
leading to a very poor therapeutic outcome with a quite low five-year survival rate. The …
leading to a very poor therapeutic outcome with a quite low five-year survival rate. The …
Chronic effects of pulsed high intensity focused ultrasound aided delivery of gemcitabine in a mouse model of pancreatic cancer
TD Khokhlova, YN Wang, H Son, S Totten, S Whang… - Ultrasonics, 2023 - Elsevier
Pulsed high intensity focused ultrasound (pHIFU) is a non-invasive method that allows to
permeabilize pancreatic tumors through inertial cavitation and thereby increase the …
permeabilize pancreatic tumors through inertial cavitation and thereby increase the …
Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles
NY Rapoport, AM Kennedy, JE Shea, CL Scaife… - Journal of Controlled …, 2009 - Elsevier
The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …
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