Epigenetic modifications work in concert with genetic mechanisms to regulate transcriptional
activity in normal tissues and are often dysregulated in disease. Although they are …

Histone proteins are subject to a diverse range of post-translational modifications which,
along with DNA methylation, play a major role in controlling gene expression, cell division …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

Abstract Epigenetic (“above genetics”) modifications can alter the gene expression without
altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA …

Alterations in the genome and the epigenome are common in most cancers. Changes in
epigenetic signatures, including aberrant DNA methylation and histone deacetylation, are …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …