Aims Voriconazole is a new triazole antifungal agent with activity against a range of clinically
important and emerging pathogens. This study determined the effect of food on the …

Aims Voriconazole is a new triazole with broad‐spectrum antifungal activity against clinically
significant and emerging pathogens. These studies evaluated the pharmacokinetics and …

Aims Voriconazole is a potent new triazole with broad‐spectrum antifungal activity against
clinically significant and emerging pathogens. The present study evaluated the safety …

The objective of this study was to investigate the safety, tolembility, and pharmacokinetics of
oral voriconazole in subjects at high risk of developing fungal infections. This was a …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Pharmacokinetic variability of
voriconazole is largely caused by CYP3A4‐and CYP2C19‐mediated metabolism.• Oral …

Voriconazole is a first-line agent in the treatment of many invasive fungal infections and is
known to display highly variable pharmacokinetics. Previous studies of voriconazole …

Voriconazole is the first available second-generation triazole with potent activity against a
broad spectrum of clinically significant fungal pathogens, including Aspergillus, Candida …

Aims Voriconazole is a new triazole antifungal agent, and is metabolized by the cytochrome
P450 isoenzymes CYP2C9, CYP2C19, and, to a lesser extent, by CYP3A4. Phenytoin is an …

In this study, the safety, tolerability, and pharmacokinetics of intravenous (iv)-to oral-dose
regimens of voriconazole were evaluated with a group of 42 healthy men, 41 of whom …

In the present study, we developed a fast and reliable HPLC assay for the determination of
the new triazole antifungal agent voriconazole in plasma, using a Chromolith® RP 18e …