Update on psoriasis immunopathogenesis and targeted immunotherapy

SK Mahil, F Capon, JN Barker - Seminars in immunopathology, 2016 - Springer
Over recent years, significant progress has been made in characterisation of the underlying
pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with …

Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis

PJ Mease, AW Armstrong - Drugs, 2014 - Springer
Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. Up to 40% of patients
with psoriasis will go on to develop PsA, usually within 5–10 years of cutaneous disease …

Immunology of psoriasis

MA Lowes, M Suarez-Farinas… - Annual review of …, 2014 - annualreviews.org
The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Psoriatic arthritis: current therapy and future approaches

DQ Huynh, A Kavanaugh - Rheumatology, 2015 - academic.oup.com
PsA is a systemic inflammatory condition that affects 20–30% of patients with psoriasis. It is
characterized by potential involvement of diverse tissues, including peripheral and axial …

Pathophysiology of psoriasis: A review

K Yamanaka, O Yamamoto… - The Journal of …, 2021 - Wiley Online Library
Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …

Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data

LI Sakkas, DP Bogdanos - Autoimmunity Reviews, 2017 - Elsevier
Psoriatic arthritis (PsA) is a psoriasis (Ps)-associated inflammatory joint disease that affects
peripheral joints, entheses, spine, and eyes. PsA and Ps are likely to be the same disease …

[HTML][HTML] Psoriatic arthritis: state of the art review

LC Coates, PS Helliwell - Clinical Medicine, 2017 - Elsevier
Psoriatic arthritis (PsA) accounts for around 20% of referrals to the early arthritis clinic and
presents a significant diagnostic and management challenge. Early diagnosis is important to …

Psoriasis: from pathogenesis to targeted therapies

C Conrad, M Gilliet - Clinical reviews in allergy & immunology, 2018 - Springer
Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks
to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with …

Inflammation and psoriasis: a comprehensive review

AM Man, MS Orăsan, OA Hoteiuc… - International Journal of …, 2023 - mdpi.com
Psoriasis is an immune-mediated disease with a strong genetic component that brings many
challenges to sick individuals, such as chronic illness, and which has multiple associated …

Insights into interplay of immunopathophysiological events and molecular mechanistic cascades in psoriasis and its associated comorbidities

AK Srivastava, TC Yadav, HK Khera, P Mishra… - Journal of …, 2021 - Elsevier
Psoriasis is an inflammatory skin disease with complex pathogenesis and multiple
etiological factors. Besides the essential role of autoreactive T cells and constellation of …