[PDF][PDF] Comparative genomic profiling of synovium versus skin lesions in psoriatic arthritis

J Belasco, JS Louie, N Gulati, N Wei… - Arthritis & …, 2015 - Wiley Online Library
Objective To our knowledge, there is no broad genomic analysis comparing skin and
synovium in psoriatic arthritis (PsA). Also, there is little understanding of the relative levels of …

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

L Grine, L Dejager, C Libert… - Cytokine & growth factor …, 2015 - Elsevier
Psoriasis is a skin disease where various cytokines play a detrimental role, yet our
understanding of the disease is still limited. TNF is a validated drug target in psoriasis and …

Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

NC Brembilla, WH Boehncke - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a common chronic inflammatory skin disease, associated with substantial
comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived …

Management of psoriasis as a systemic disease: what is the evidence?

NJ Korman - British Journal of Dermatology, 2020 - academic.oup.com
Background Psoriasis is a chronic, systemic immune‐mediated disease characterized by
development of erythematous, indurated, scaly, pruritic and often painful skin plaques …

Comprehensive treatment of psoriatic arthritis: managing comorbidities and extraarticular manifestations

A Ogdie, S Schwartzman, L Eder, AB Maharaj… - The Journal of …, 2014 - jrheum.org
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis that can lead to
decreased health-related quality of life and permanent joint damage leading to functional …

Does biologic therapy impact the development of PsA among patients with psoriasis?

E Meer, JF Merola, R Fitzsimmons, TJ Love… - Annals of the …, 2022 - ard.bmj.com
Objective To examine the association of biologic therapy use for psoriasis with incident
psoriatic arthritis (PsA) diagnosis. Methods A retrospective cohort study was conducted in …

Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints

MA Boutet, A Nerviani, G Gallo Afflitto… - International journal of …, 2018 - mdpi.com
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

[HTML][HTML] From empirical to pathogenesis-based treatments for psoriasis

PCM van de Kerkhof - Journal of Investigative Dermatology, 2022 - Elsevier
Since the foundation of the European Society for Dermatological Research, pathogenesis of
psoriasis has been studied by many research groups, focusing on various compartments of …

Major role of the IL17/23 axis in psoriasis supports the development of new targeted therapies

H Bugaut, S Aractingi - Frontiers in Immunology, 2021 - frontiersin.org
Psoriasis is a frequent, chronic disease characterized by cutaneous inflammatory plaques
and/or arthritis. It may be associated with few other diseases, mainly Crohn's disease and …

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

MA Lowes, CB Russell, DA Martin, JE Towne… - Trends in …, 2013 - cell.com
Psoriasis is a complex inflammatory process resulting from activation of the well-defined
interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in …