Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status

MJ Ramirez, MKP Lai, RM Tordera, PT Francis - Drugs, 2014 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in elderly people.
Research focused on identifying compounds that restore cognition and memory in AD …

Role of serotonin in Alzheimer's disease: a new therapeutic target?

WJ Geldenhuys, CJ Van der Schyf - CNS drugs, 2011 - Springer
Mounting evidence accumulated over the past few years indicates that the neurotransmitter
serotonin plays a significant role in cognition. As a drug target, serotonin receptors have …

Serotonergic drugs: agonists/antagonists at specific serotonergic subreceptors for the treatment of cognitive, depressant and psychotic symptoms in Alzheimer's …

FM Werner, R Covenas - Current pharmaceutical design, 2016 - ingentaconnect.com
Background: Alzheimer's disease is a neurodegenerative disease showing alterations in
classical neurotransmitters, above all in the hippocampus and prefrontal/temporal cortices …

Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status

H Ferrero, M Solas, PT Francis, MJ Ramirez - CNS drugs, 2017 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …

[HTML][HTML] The role of serotonin receptors in Alzheimer's disease

M Butzlaff, E Ponimaskin - Opera Medica et Physiologica, 2016 - cyberleninka.ru
Alzheimer's disease (AD) is the most common cause of dementia with an increasing impact
on the aging society. Although generations of researchers tried to unravel the …

The serotonergic system in ageing and Alzheimer's disease

JJ Rodríguez, HN Noristani, A Verkhratsky - Progress in neurobiology, 2012 - Elsevier
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease

TW Chow, BG Pollock, NW Milgram - … disease and treatment, 2007 - Taylor & Francis
Objective Selective serotonin reuptake inhibitors (SSRIs) have increased cognitive
performance in some clinical studies of Alzheimer's disease (AD), but it is has been difficult …

The treatment of cognitive impairment in Alzheimer's disease: beyond the cholinergic approach

M Davidson, RG Stem - Psychiatric Clinics of North America, 1991 - Elsevier
Despite the well-founded rationale for the use of cholinomimetic and monoaminergic agents
in the treatment of Alzheimer's disease, thus far, these strategies have only led to modest …

Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder

M Lozupone, M La Montagna, F D'Urso… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Pharmacotherapy for the treatment of depressive disorders in Alzheimer's
Disease (AD) represents a clinical challenge. pharmacological options are often attempted …

[HTML][HTML] Chemical update on the potential for serotonin 5-HT6 and 5-HT7 receptor agents in the treatment of Alzheimer's disease

K Kucwaj-Brysz, H Baltrukevich, K Czarnota… - Bioorganic & Medicinal …, 2021 - Elsevier
Despite the better understanding of the mechanisms underlying Alzheimer's Disease (AD)
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …