Application of fecal volatile organic compound analysis in clinical practice: Current state and future perspectives

S El Manouni el Hassani, DJC Berkhout, S Bosch… - Chemosensors, 2018 - mdpi.com
Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as
non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs …

Characteristics of fecal metabolic profiles in patients with irritable bowel syndrome with predominant diarrhea investigated using 1H‐NMR coupled with multivariate …

JS Lee, SY Kim, YS Chun, YJ Chun… - …, 2020 - Wiley Online Library
Background Gut microbiota are known to be closely related to irritable bowel syndrome
(IBS). However, not much is known about characteristic fecal metabolic profiles of IBS. We …

Integrated fecal microbiome–metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

Z Mujagic, M Kasapi, DMAE Jonkers, I Garcia-Perez… - Gut …, 2022 - Taylor & Francis
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS),
several modalities of biological and clinical data must be combined. We aimed to identify …

Application of metabolomics to the study of irritable bowel syndrome

SM Bennet, AH Keshteli, P Bercik… - …, 2020 - Wiley Online Library
The pathophysiology of irritable bowel syndrome and the detection of biomarkers of specific
mechanisms and/or predictors of therapeutic response remain elusive. This roadblock …

Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome

G Gargari, V Taverniti, C Gardana… - Environmental …, 2018 - Wiley Online Library
Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified
according to bowel habits as IBS with constipation (IBS‐C), with diarrhea (IBS‐D), with …

Metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with inflammatory bowel disease: a pilot study

N Patel, N Alkhouri, K Eng, F Cikach… - Alimentary …, 2014 - Wiley Online Library
Background Breath testing is becoming an important diagnostic method to evaluate many
disease states. In the light of rising healthcare costs, is important to develop a simple non …

High-dimensional clustering of 4000 irritable bowel syndrome patients reveals seven distinct disease subsets

A Byale, RJ Lennon, S Byale, M Breen-Lyles… - Clinical …, 2022 - Elsevier
Background and Aims Irritable bowel syndrome (IBS) is a pain disorder classified by bowel
habits, disregarding other factors that may influence the clinical course. The aim of this study …

Use of biomarkers in irritable bowel syndrome: to predict the future, look at the past

R Sood, AC Ford - Clinical and Translational Gastroenterology, 2015 - journals.lww.com
As clinicians, we are trained to make a positive diagnosis of irritable bowel syndrome (IBS),
by using a combination of the most pertinent parts of the patient history, physical …

[HTML][HTML] Differences in fecal microbiomes and metabolomes of people with vs without irritable bowel syndrome and bile acid malabsorption

IB Jeffery, A Das, E O'Herlihy, S Coughlan, K Cisek… - Gastroenterology, 2020 - Elsevier
Background & Aims Irritable bowel syndrome (IBS) is a heterogeneous disorder, but
diagnoses and determination of subtypes are made based on symptoms. We profiled the …

Mucosa-associated microbiota in patients with irritable bowel syndrome: a comparison of subtypes

H Matsumoto, A Shiotani, R Katsumata, S Fukushima… - Digestion, 2021 - karger.com
Background: Most studies on gut microbiome of irritable bowel syndrome (IBS) have focused
on fecal microbiota, instead of mucosa-associated microbiota (MAM). Aims: The aim of this …