Solution structure of a 2: 1 quindoline–c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design
Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
[HTML][HTML] Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …
Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex
The structural differences among different G-quadruplexes provide an opportunity for site-
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization
The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter strongly controls
the transcriptional activity of the c-MYC oncogene. The purine-rich strand of the NHE III1 …
the transcriptional activity of the c-MYC oncogene. The purine-rich strand of the NHE III1 …
Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes
We report bis-phenylethynyl amide derivatives as a potent G-quadruplex binding small
molecule scaffold. The amide derivatives were efficiently prepared in 3 steps by employing …
molecule scaffold. The amide derivatives were efficiently prepared in 3 steps by employing …
Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
J Dickerhoff, J Dai, D Yang - Nucleic Acids Research, 2021 - academic.oup.com
Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from the intron of the N-myc gene
M Trajkovski, M Webba da Silva… - Journal of the American …, 2012 - ACS Publications
A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA
oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the …
oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the …
Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
R Chaudhuri, S Bhattacharya, J Dash… - Journal of Medicinal …, 2020 - ACS Publications
Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution
J Dai, TS Dexheimer, D Chen, M Carver… - Journal of the …, 2006 - ACS Publications
We report the first G-quadruplex structure formed in the promoter region of the human bcl-2.
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
Sequence, stability, and structure of G‐quadruplexes and their interactions with drugs
Y Chen, D Yang - Current protocols in nucleic acid chemistry, 2012 - Wiley Online Library
Although DNA is most widely known for its ability to store and pass along genetic
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …