Natural metabolites present an extraordinary chemo-diversity and have been used as the
inspiration for new drugs. Considering the need for new treatments against the neglected …

New therapeutic options against leishmaniasis are necessary, especially those of natural
origin, like licarin A, a neolignan with activity against Leishmania major. The effect of licarin …

Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-
term administration, expensive drugs associated with severe side effects. Considering these …

This study was performed to investigate the mechanistic aspects of cell death induced by a
clerodane diterpene (K-09) in Leishmania donovani promastigotes that was previously …

Leishmaniases are neglected infectious diseases caused by parasites of the
'protozoan'genus Leishmania. Depending on the parasite species, different clinical forms …

The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of
pentamidine have been investigated, and all compounds assayed were found to display …

Anti-leishmanial treatment increasingly encounters therapeutic limitations due to drug
toxicity and development of resistance. The effort for new therapeutic strategies led us to …

ABSTRACT Miltefosine (hexadecylphosphocholine [HePC]) is currently on trial as a first-
choice, orally active drug for the treatment of visceral leishmaniasis when resistance to …

In the search for new compounds with antileishmanial activity, we synthesized a triazole
hybrid analogue of the neolignans grandisin and machilin G (LASQUIM 25), which was …

The in vitro activity against Leishmania spp. of five novel designed compounds,
phenalenone derivatives, is described in this study. Previous works have shown that some …