Natural products (NPs) have historically played a primary role in the discovery of small-
molecule drugs. However, due to the advent of other methodologies and the drawbacks of …

Dereplication represents a key step for rapidly identifying known secondary metabolites in
complex biological matrices. In this context, liquid-chromatography coupled to high …

Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …

The discovery of novel and/or new bioactive natural products from biota sources is often
confounded by the reisolation of known natural products. Dereplication strategies that …

Highlights•Natural products are advancing a dynamic comeback in drug
discovery.•Advances in NMR play a vital role in the identification of natural products.• …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

Complete structural elucidation of natural products is commonly performed by nuclear
magnetic resonance spectroscopy (NMR), but annotating compounds to most likely …

Natural products are an indispensable source for drug discovery. The major challenge for
exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable …

Strategies for natural product dereplication are continually evolving, essentially in lock step
with advances in MS and NMR techniques. MADByTE is a new platform designed to identify …

Research in natural products has always enhanced drug discovery by providing new and
unique chemical compounds. However, recently, drug discovery from natural products is …