Background and Purpose: The Coxiella burnetii phase-I cellular vaccine is efficacious in
humans, imparting nearly complete protection against Q fever. However, this vaccine can …

ABSTRACT Q fever is an infectious disease caused by Coxiella burnetii, an obligate
intracellular bacterium that replicates in macrophages. As cell-mediated immune response …

The inability to propagate obligate intracellular pathogens under axenic (host cell-free)
culture conditions imposes severe experimental constraints that have negatively impacted …

Development of vaccines that are both safe and effective remains a costly and time-
consuming challenge. To accelerate the pace of development and improve the efficacy and …

ABSTRACT Q fever is a worldwide zoonosis caused by Coxiella burnetii, a strictly
intracellular bacterium that is a potential bioweapon. Humans usually acquires Q fever after …

Q fever is caused by the obligate intracellular bacterium Coxiella burnetii. In vitro growth of
the bacterium is usually limited to viable eukaryotic host cells imposing experimental …

Coxiella burnetii, the agent of human Q fever, is a zoonotic bacterial pathogen with a
worldwide distribution. Owing to an historic lack of methods for genetic manipulation …

Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that has a
tropism for cells of the mononuclear phagocyte system. Following internalization, C. burnetii …

Coxiella burnetii is the causative agent of Q fever, a disease with a spectrum of
presentations from the mild to fatal, including chronic sequelae. Since its discovery in 1935 …

Coxiella burnetii is a Gram-negative bacterium that causes Q fever in humans. In the present
study, 131 candidate peptides were selected from the major immunodominant proteins …