Epigenetic modifications at the histone level affect gene regulation in response to
extracellular signals,. However, regulated epigenetic modifications at the DNA level …

The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and
has a role in gene silencing 1, 2, 3, 4. DNA methylation represses genes partly by …

Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

The structure of chromatin—the material of which eukaryotic chromosomes are composed—
presents both problems and opportunities to the transcriptional machinery. Genes are …

Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1
(LSD1) causes either gene repression or activation,. As a component of co-repressor …

Methylation of CpG dinucleotides is generally associated with epigenetic silencing of
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …

Abstract Development is often assumed to be hardwired in the genome, but several lines of
evidence indicate that it is susceptible to environmental modulation with potential long-term …

This paper tests the hypothesis that expression of the DNA methyltransferase, dnmt1, gene
is regulated by a methylation‐sensitive DNA element. Methylation of DNA is an attractive …

MBD2 is the only member of a family of methyl-CpG-binding proteins that has been reported
to be both a transcriptional repressor and a DNA demethylase (dMTase). To understand the …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …