Hepatocellular carcinoma (HCC) is one of the most common solid tumors worldwide,
characterized by clinical aggressiveness, resistance to conventional chemotherapy, and …

Cell metabolism abnormalities are closely related to tumor occurrence and development.
Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis. Increasing …

Background & Aims Cumulating evidence underlines the crucial role of aberrant lipogenesis
in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of …

Hepatocellular carcinoma (HCC) is one of the most frequent and deadly malignancies
worldwide. Studies are urgently needed on its molecular pathogenesis and biological …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an
aggressive cancer type with limited treatment options. Cumulating evidence underlines a …

In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have
been independently described in many tumour types, including hepatocellular carcinoma …

Human fatty acid synthase (FASN) is a 270-kDa cytosolic dimeric enzyme that is responsible
for palmitate synthesis. FASN is slowly emerging and rediscovered as a marker for …

While normal tissues are tightly regulated by nutrition and a carefully balanced system of
glycolysis and fatty acid synthesis, tumor cells are under significant evolutionary pressure to …