The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in
angiogenesis, heart disease, and cancer. LT1009 (also known as sonepcizumab) is a …

Identification of differentially expressed proteins in antiphospholipid syndrome (APS) is a
developing area of research for unique profiles of this pathology. Advances in technologies …

The enzyme phospholipase C gamma 1 (PLCγ1) has been identified as a potential drug
target of interest for various pathological conditions such as immune disorders, systemic …

AD is a common disease among other neurodegenerative disorders primarily developing
due to amyloid-β (Aβ) neurotoxicity derived from the amyloid-β protein precursor (AβPP) …

Atherosclerosis, the underlying pathology of most cardiovascular diseases, is triggered by
the retention of apolipoprotein B (apoB)-containing lipoproteins in the arterial wall through …

Background. The persistent presence of antiphospholipid antibodies (APA) may lead to the
development of primary or secondary antiphospholipid syndrome. Although the genetic …

Objective Natural autoantibodies have been implicated to play a key role in the
pathogenesis of coronary heart disease (CHD) because they augment autoimmune …

Computer-aided antibody engineering has been successful in the design of new biologics
for disease diagnosis and therapeutic interventions. Interleukin-6 (IL-6), a well-recognized …

Objectives: A growing body of studies related to antiphospholipid syndrome (APS) have
been published in recent years. Nevertheless, there is a lack of visualized and systematic …

Inflammatory cells are involved throughout the course of atherosclerosis, which therefore is
often considered an inflammatory disease; however, atherosclerosis has important features …