Crystal structure of the polo-box domain of polo-like kinase 2
HM Shan, T Wang, JM Quan - Biochemical and biophysical research …, 2015 - Elsevier
Abstract Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression, DNA
damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal …
damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal …
Polo-box domain: a versatile mediator of polo-like kinase function
Members of the polo subfamily of protein kinases have emerged as important regulators in
diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests …
diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests …
Structural analysis of the polo‐box domain of human Polo‐like kinase 2
JH Kim, B Ku, KS Lee, SJ Kim - Proteins: Structure, Function …, 2015 - Wiley Online Library
Polo‐like kinases (Plks) are the key regulators of cell cycle progression, the members of
which share a kinase domain and a polo‐box domain (PBD) that serves as a protein …
which share a kinase domain and a polo‐box domain (PBD) that serves as a protein …
[HTML][HTML] The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain
AEH Elia, P Rellos, LF Haire, JW Chao, FJ Ivins… - Cell, 2003 - cell.com
Polo-like kinases (Plks) perform crucial functions in cell-cycle progression and multiple
stages of mitosis. Plks are characterized by a C-terminal noncatalytic region containing two …
stages of mitosis. Plks are characterized by a C-terminal noncatalytic region containing two …
[HTML][HTML] Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance
Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key regulator of
various cell cycle events that are critical for proper M-phase progression. The polo-box …
various cell cycle events that are critical for proper M-phase progression. The polo-box …
[HTML][HTML] Polo-box domains confer target specificity to the Polo-like kinase family
BCM van de Weerdt, DR Littler, R Klompmaker… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Polo-like kinases (Plks) contain a conserved Polo-box domain, shown to bind to
phosphorylated Ser-pSer/pThr-Pro motifs. The Polo-box domain of Plk-1 mediates substrate …
phosphorylated Ser-pSer/pThr-Pro motifs. The Polo-box domain of Plk-1 mediates substrate …
Structural basis for the inhibition of Polo-like kinase 1
Abstract Polo-like kinase 1 (PLK1) is a master regulator of mitosis and is considered a
potential drug target for cancer therapy. PLK1 is characterized by an N-terminal kinase …
potential drug target for cancer therapy. PLK1 is characterized by an N-terminal kinase …
From Plk1 to Plk5: functional evolution of polo-like kinases
Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …
Understanding the polo kinase machine
V Archambault, G Lepine, D Kachaner - Oncogene, 2015 - nature.com
Abstract The Polo Kinase is a central regulator of cell division required for several events of
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …
Structure and function of Polo-like kinases
Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-
like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region …
like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region …