Neuropathic pain is responsible for a significant amount of the morbidity associated with
generalized and focal peripheral neuropathies. It is a consequence of alterations in …

Positive allosteric modulators of GABAA receptors (GAMs) acting at specific subtypes of
GABAA receptors effectively restore compromised spinal pain control in rodents. Studies …

The focus of perioperative pain management should be to attempt to minimise the
nociceptive input and reduce the risk of transition to central sensitisation. Gabapentinoids …

Background Clinical management of neuropathic pain, which is pain arising as a
consequence of a lesion or a disease affecting the somatosensory system, partly relies on …

Antiepileptic drugs (AEDs) are often utilized in the treatment of neuropathic pain. The major
AED valproic acid (VPA) is of particular interest as it is thought to engage a variety of …

Inflammation causes sensitization of peripheral and central nociceptive neurons.
Pharmacological modulation of the latter has successfully been used for clinical pain relief …

Sodium channel blockers such as lidocaine, lamotrigine, and carbamazepine can be
effective in the treatment of neuropathic pain. Though not approved for neuropathic pain …

Upregulation of Ca2+-permeable AMPA receptors (CP-AMPARs) in the dorsal horn (DH)
neurons of the spinal cord has been causally linked to the maintenance of persistent …

Considerable evidence demonstrated that the central role of reactive oxygen species and
reactive nitrogen species (ROS and RNS) in the development of thermal hyperalgesia is …

Our knowledge about the pathogenesis of neuropathic pain has grown significantly during
last two decades. Basic research with animal models of neuropathic pain and human clinical …