TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding
Rhabdomyosarcoma (RMS) is an aggressive pediatric cancer composed of myoblast-like
cells. Recently, we discovered a unique muscle progenitor marked by the expression of the …
cells. Recently, we discovered a unique muscle progenitor marked by the expression of the …
Twist1 is essential in maintaining mesenchymal state and tumor-initiating properties in synovial sarcoma
Synovial sarcoma is an aggressive mesenchymal tumor with dual differentiation; epithelial
and mesenchymal differentiation. However, the molecular mechanisms behind …
and mesenchymal differentiation. However, the molecular mechanisms behind …
Twist is a potential oncogene that inhibits apoptosis
R Maestro, AP Dei Tos, Y Hamamori… - Genes & …, 1999 - genesdev.cshlp.org
Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must
depend, in part, on compensating mutations that protect from programmed cell death. A …
depend, in part, on compensating mutations that protect from programmed cell death. A …
[HTML][HTML] Multiple biological functions of Twist1 in various cancers
Z Zhao, MA Rahman, ZG Chen, DM Shin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Twist1 is a well-known regulator of transcription during embryonic organogenesis in many
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …
The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through twist activation
Twist has been shown to cause treatment failure, cancer progression, and cancer-related
death. However, strategies that directly target Twist are not yet conceivable. Here we reveal …
death. However, strategies that directly target Twist are not yet conceivable. Here we reveal …
RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis
S Sánchez-Molina, E Figuerola-Bou, E Blanco… - Science …, 2020 - science.org
Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults.
EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that …
EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that …
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
S Pomella, P Sreenivas, BE Gryder, L Wang… - Nature …, 2021 - nature.com
Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …
TWIST1 promotes invasion through mesenchymal change in human glioblastoma
SA Mikheeva, AM Mikheev, A Petit, R Beyer… - Molecular cancer, 2010 - Springer
Background Tumor cell invasion into adjacent normal brain is a mesenchymal feature of
GBM and a major factor contributing to their dismal outcomes. Therefore, better …
GBM and a major factor contributing to their dismal outcomes. Therefore, better …
[HTML][HTML] Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells
RP Gajula, ST Chettiar, RD Williams, K Nugent, Y Kato… - Neoplasia, 2015 - Elsevier
The TWIST1 gene has diverse roles in development and pathologic diseases such as
cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH) transcription factor existing as …
cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH) transcription factor existing as …