Peripheral Artery Disease: Molecular Mechanisms and Novel Therapies

A Athavale, E Fukaya, NJ Leeper - … , Thrombosis, and Vascular …, 2024 - Am Heart Assoc
These clinical conditions are among the strongest risk factors for PAD. A common
mechanism they share includes oxidative stress, driven by an imbalance of reactive oxygen …

The pathophysiology of peripheral arterial disease: rational targets for drug intervention

JP Cooke - Vascular Medicine, 1997 - journals.sagepub.com
The most common cause of peripheral arterial disease (PAD) is atherosclerosis, which
begins with an alteration in endothelial biology due to hypercholesterolemia, diabetes …

Biomarkers and genetics in peripheral artery disease

S Hazarika, BH Annex - Clinical chemistry, 2017 - academic.oup.com
BACKGROUND Peripheral artery disease (PAD) is highly prevalent and there is
considerable diversity in the initial clinical manifestation and disease progression among …

[HTML][HTML] Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease

NK Malhi, KW Southerland, L Lai… - Methodist DeBakey …, 2023 - ncbi.nlm.nih.gov
Peripheral arterial disease (PAD) represents a global health concern with a rising
prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among …

[图书][B] Peripheral arterial disease: pathophysiology and therapeutics

CG Kevil, SC Bir, CB Pattillo - 2013 - books.google.com
Peripheral arterial disease (PAD) is a cardiovascular disorder of the peripheral vasculature
due to progressive atherosclerotic stenosis of conduit arteries restricting blood flow to …

Peripheral vascular disease in 2021

NJ Leeper, NM Hamburg - Circulation research, 2021 - Am Heart Assoc
It seems fitting in this year of isolation and pandemic to open the Compendium on Peripheral
Vascular Diseases with the voices of patients. Gertrude Campbell was a pioneer as the first …

Novel markers of peripheral arterial disease

FJ Khawaja, IJ Kullo - Vascular Medicine, 2009 - journals.sagepub.com
Peripheral arterial disease (PAD), a relatively common manifestation of atherosclerotic
vascular disease, is associated with significant morbidity and mortality. Although …

The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions

IJ Kullo, NJ Leeper - Circulation research, 2015 - Am Heart Assoc
Several risk factors for atherosclerotic peripheral arterial disease (PAD), such as
dyslipidemia, diabetes mellitus, and hypertension, are heritable. However, predisposition to …

Diabetes mellitus in peripheral artery disease: Beyond a risk factor

MV Singh, AO Dokun - Frontiers in cardiovascular medicine, 2023 - frontiersin.org
Peripheral artery disease (PAD) is one of the major cardiovascular diseases that afflicts a
large population worldwide. PAD results from occlusion of the peripheral arteries of the …

Integrating mechanisms in thrombotic peripheral arterial disease

M Nagy, PEJ van der Meijden, J Glunz, L Schurgers… - Pharmaceuticals, 2022 - mdpi.com
Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is
underdiagnosed in the general population. Despite the extensive research performed to …