Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

Osteoarthritis (OA) is the leading cause of disability in older persons, affecting 10% of the
population 60 years of age. In the United States alone, there are currently at least 20 million …

Traditionally, osteoarthritis (OA) has been conceptualized as a disease whose central
pathologic feature is hyaline articular cartilage loss. More recently, OA has been relabeled …

Osteoarthritis (OA) currently affects over 40 million Europeans, with its associated personal
suffering and significant economic burden for health systems set to dramatically escalate in …

Perhaps the most important change in OA over the past 60 years has been in attitudes rather
than knowledge. OA has changed from being a boring, degenerative form of joint pathology …

Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate
and adaptive immune systems accompanied by inflammation exemplified by the elevated …

Osteoarthritis (OA) has been a frustrating disease for both the patient and the physician. Its
current impact on society is tremendous and rivals that of ischemic heart disease in many …

Osteoarthritis (OA) can be a progressive, disabling disease, leading to diminished quality of
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …

Osteoarthritis (OA) is considered to be primarily a disease of the hyaline articular cartilage,
which secondarily affects subchondral bone and synovial membrane. The exact nature and …

New treatment options are needed for osteoarthritis (OA) to slow down the structural
progression of the disease; current therapies mostly target pain and function with minimal …