Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system,
usually occurring in young adults and leading to disability. Despite the progress in …

Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with
multifocal areas of demyelination. Although its etiology and pathogenesis remain …

The objective of this study was to investigate, whether the presence of oligoclonal
immunoglobulin M bands (IgM‐OCB) in cerebrospinal fluid (CSF) from patients with a …

Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …

The majority of patients presenting with a first clinical symptom suggestive of multiple
sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to …

Background and purpose The gold standard for detection of intrathecal immunoglobulin
synthesis is the measurement of oligoclonal bands (OCB). In the diagnosis of multiple …

Background Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more
than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we …

Intrathecal IgM synthesis was assessed through the detection of oligoclonal bands in
cerebrospinal fluid (CSF) and through calculation of IgM index values and total CSF IgM …

Importance Reliable biomarkers associated with disability worsening in multiple sclerosis
(MS) are still needed. Objective To determine a possible association of intrathecal IgG …

Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS).
For many candidate biomarkers CSF is the only fluid that can be investigated. Several …