The intrathecal humoral immune response: laboratory analysis and clinical relevance

CJM Sindic, MPV Antwerpen, S Goffette - 2001 - degruyter.com
In normal conditions, albumin and immunoglobulin (Ig) G in the cerebrospinal fluid (CSF)
originate from the blood, and there is no antibody production within the central nervous …

[PDF][PDF] Combined use of kappa free light chain index and isoelectrofocusing of cerebro-spinal fluid in diagnosing multiple sclerosis: performances and costs

I Crespi, MG Sulas, R Mora, P Naldi, D Vecchio… - Clin Lab, 2017 - researchgate.net
Background: Isoelectrofocusing (IEF) to detect oligoclonal bands (OBCs) in cerebrospinal
fluid (CSF) is the gold standard approach for evaluating intrathecal immunoglobulin …

Can CSF biomarkers predict future MS disease activity and severity?

R Magliozzi, AH Cross - Multiple Sclerosis Journal, 2020 - journals.sagepub.com
Multiple sclerosis (MS) is a heterogeneous disease. With several disease modifying
treatments of different mechanisms of action in use now and in development, it is important …

The predictive value of intrathecal immunoglobulin synthesis and magnetic resonance imaging in acute isolated syndromes for subsequent development of multiple …

MK Sharief, EJ Thompson - … of Neurology: Official Journal of the …, 1991 - Wiley Online Library
The intrathecal synthesis of IgM in patients presenting with acute monosymptomatic
syndromes may be relevant in predicting eventual progression to multiple sclerosis but has …

Immunophenotyping of cerebrospinal fluid cells in multiple sclerosis: in search of biomarkers

S Alvermann, C Hennig, O Stüve, H Wiendl… - JAMA …, 2014 - jamanetwork.com
Importance Cerebrospinal fluid (CSF) is the compartment in closest proximity to the central
nervous system (CNS) parenchyma and might reflect immune pathology in inflammatory …

Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination …

C Jacobi, P Lange, H Reiber - Journal of neuroimmunology, 2007 - Elsevier
The detection of intrathecal antibody synthesis by qualitative methods or the Antibody-Index
(AI) is a relevant tool for diagnosis of inflammatory neurological diseases. An increased AI …