Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years,
exciting advances have been made in the understanding of its pathophysiology and …

Infections that result in shock and organ failure are a major public health problem worldwide.
Severe sepsis and septic shock affect patients of all ages and often complicate chronic …

A detailed discussion of these measures is beyond the scope of this article, but several
general principles emerge. Firstly, it is essential to ensure adequate oxygenation and to …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …

Over the past 30 years, 2 major factors have led to a perceived need for better definitions. In
particular, the increasing sophistication, at least in high-income countries, of modalities …

The complexity of treating severe sepsis and septic shock has been elucidated in myriad
studies, particularly in the past 10 years. The development of clinical guidelines, insight into …

Sepsis is a life-threatening organ dysfunction that results from the body's response to
infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic …

Severe sepsis and septic shock are as common and lethal as other acute life-threatening
conditions that emergency physicians routinely confront such as acute myocardial infarction …