This case illustrates well the fact that antihypertensive therapy does not significantly reduce
the risk of acute myocardial infarction, nor does it necessarily lead to regression of left …

Angiotensin II (Ang II), an important peptide in cardiovascular physiology, is the product of
enzymatic processing of angiotensinogen which involves two proteolytic steps carried out by …

Angiotensin-converting enzyme inhibitors have proven to be uniquely effective in inducing
regression, or preventing the occurrence, of ventricular hypertrophy associated with …

The tissue renin-angiotensin system plays an integral role in the homeostasis of blood
pressure and in the pathogenesis of cardiovascular remodeling. These effects are primarily …

Angiotensin has many different actions, most of which relate, either directly or indirectly, to
the regulation of blood pressure, fluid, and electrolyte homeostasis (1, 2). In addition to …

During the last decade, our knowledge about the syn-thesis, target tissues and actions of
angiotensin II has increased considerably. Local generation and paracrine or autocrine …

The unique efficacy of converting-enzyme inhibitors in inducing regression, or preventing
the occurrence, of ventricular hypertrophy associated with systemic hypertension has for …

Immunohistochemical studies and experiments with microdissected nephron segments
indicate that the angiotensin I converting enzyme (ACE) in the kidney is expressed in the …

A growing body of evidence suggests that angiotensin II, the effector protein of the renin-
angiotensin system, is intimately involved with cell growth in target tissues. Most recently …

Recent findings support the existence of independently functioning, local renin-angiotensin
systems in a number of tissues. The clinical importance that inhibitors of the renin …