Background: Oxi4503 has been shown to inhibit tumor growth and improve survival in an
animal model of colorectal (CRC) liver metastases. This agent appears to selectively target …

Background The outcomes for patients with advanced hepatocellular carcinoma (HCC)
receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib …

Objective: To assess the effects of preoperative systemic chemotherapy on remnant liver
parenchyma, liver function, and morbidity after major liver resection for colorectal liver …

Background Advances in neoadjuvant therapy enabled novel strategies for treating
resectable and initially unresectable colorectal cancer liver metastases. Although it is well …

Background and aims Neoadjuvant chemotherapy is increasingly being used to enlarge the
cohort of patients who can be offered hepatic resection for malignancy. However, the impact …

Hepatocellular carcinoma (HCC) treatment is challenging because the mechanisms
underlying tumor progression are still largely unknown. Transforming growth factor (TGF) …

Introduction Liver resection (LR) in patients with liver metastasis from colorectal cancer
remains the only curative treatment. Perioperative chemotherapy improves prognosis of …

Liver metastases are a major cause of colorectal cancer death, and the perioperative period
is believed to critically affect the metastatic process. Here we tested whether blocking excess …

Nuclear factor‐kappaB (NFkB) plays a pivotal role in cancer progression. In this study, we
developed a decoy cis‐element oligo‐deoxyribonucleic acid against NFkB‐binding site …

Liver metastasis represents a common systemic complication of colorectal cancers (CRCs).
Partial liver resection has been demonstrated to result in long‐term survival in certain well …