[PDF][PDF] Synthesis, Docking and Evaluation of Novel Pyr-azole Carboxamide Derivatives as Mul-tifunctional Anti-Alzheimer's Agents.(2017) J Med Chem Toxicol 2 (1): 1 …
V Lather - J Med Chem Toxicol, 2017 - researchgate.net
Alzheimer's disease (AD) is a major public health problem. The dual inhibitors of
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
[HTML][HTML] Synthesis and biological activities of pyridine N-oxide bearing 5-aminoisoxazoles as potential acetylcholinesterase and monoamine oxidase inhibitors for …
LY Saleh, S Özdemir, BN Sağlık, HA Döndaş… - Journal of Molecular …, 2024 - Elsevier
A series of ten novel pyridine N-oxide-bearing 5-aminoisoxazoles was efficiently
synthesized in moderate yields by reacting 2-(cyanomethyl) pyridine 1-oxide with α …
synthesized in moderate yields by reacting 2-(cyanomethyl) pyridine 1-oxide with α …
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multiple factors
associated with its pathogenesis. Our strategy against AD involves design of multi-targeted 2 …
associated with its pathogenesis. Our strategy against AD involves design of multi-targeted 2 …
Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
Development of novel carbazole derivatives with effective multifunctional action against Alzheimer's diseases: design, synthesis, in silico, in vitro and in vivo …
Carbazole based novel multifunctional agents has been rationally designed and
synthesized as potential anti-Alzheimer agents. Multi-functional activity of these derivatives …
synthesized as potential anti-Alzheimer agents. Multi-functional activity of these derivatives …
[HTML][HTML] Structure based design, synthesis of novel fused triazole-thiazole derivatives and their comparative study on Alzheimer disease along with in silico modeling
In this approach, fused triazole thiazole derivatives (1–14) were synthesized and designed
as dual inhibitors of AChE and BuChE which exhibit promising inhibitory activity to cure one …
as dual inhibitors of AChE and BuChE which exhibit promising inhibitory activity to cure one …
[HTML][HTML] Design, Synthesis, in vitro biological evaluation and in silico molecular docking study of chloro substituted Benzimidazole-Thiazole hybrid derivatives as …
In order to explore new acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …
Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents
SK Sinha, SK Shrivastava - Bioorganic & medicinal chemistry, 2013 - Elsevier
Some new semicarbazones of 4-aminopyridine were synthesized and evaluated for
antiamnesic, cognition enhancing and anticholinesterase activities. The results illustrated a …
antiamnesic, cognition enhancing and anticholinesterase activities. The results illustrated a …
Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease
Based on the quantitative structure-activity relationship (QSAR), some novel p-
aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were …
aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were …
Synthesis, characterization, molecular docking and molecular dynamics simulations of novel 2, 5-disubstituted-1, 3, 4-thiadiazole derivatives as potential …
Designing multi-targeted drugs (MTD) for Alzheimer's disease (AD) is now one of the
priorities for medicinal chemists, as the disease has a complicated not fully understood …
priorities for medicinal chemists, as the disease has a complicated not fully understood …