Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy

MJH Coenen, JM Hofstra, H Debiec… - Journal of the …, 2013 - journals.lww.com
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic
membranous nephropathy (iMN). Our recent genome-wide association study showed that …

[HTML][HTML] Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy

D Kanigicherla, J Gummadova, EA McKenzie… - Kidney international, 2013 - Elsevier
Antibodies to the phospholipase A2 receptor 1 (PLA2R1) have been reported in 70% of
cases of idiopathic membranous nephropathy (IMN). The genetic susceptibility of IMN has …

Single Nucleotide Polymorphisms in the Phospholipase A2 Receptor Gene Are Associated with Genetic Susceptibility to Idiopathic Membranous Nephropathy

S Kim, HJ Chin, KY Na, S Kim, J Oh, W Chung… - Nephron Clinical …, 2011 - karger.com
Background: The phospholipase A2 receptor (PLA2R) is a major antigen found in patients
with idiopathic membranous nephropathy (MN). The relationship of genetic polymorphisms …

PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians

R Ramachandran, V Kumar, A Kumar… - Nephrology Dialysis …, 2016 - academic.oup.com
Background Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical
activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 …

Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy

J Lv, W Hou, X Zhou, G Liu, F Zhou… - Journal of the …, 2013 - journals.lww.com
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-
DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European …

Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy

B Seitz-Polski, G Dolla, C Payré… - Journal of the …, 2016 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting …

Clinical relevance of domain-specific phospholipase A2 receptor 1 antibody levels in patients with membranous nephropathy

L Reinhard, G Zahner, S Menzel… - Journal of the …, 2020 - journals.lww.com
Background Antibodies against phospholipase A 2 receptor 1 (PLA 2 R1) are found in 80%
of patients with membranous nephropathy, and previous studies described three …

PLA2R-associated membranous glomerulopathy is modulated by common variants in PLA2R1 and HLA-DQA1 genes

M Saeed, ML Beggs, PD Walker, CP Larsen - Genes & Immunity, 2014 - nature.com
Membranous glomerulopathy (MG) is most commonly caused by autoantibodies directed
against the podocyte phospholipase A2 receptor (PLA2R1) and common variants in this …

Genetics of membranous nephropathy

S Gupta, A Köttgen, E Hoxha… - Nephrology Dialysis …, 2018 - academic.oup.com
An HLA-DR3 association with membranous nephropathy (MN) was described in 1979 and
additional evidence for a genetic component to MN was suggested in 1984 in reports of …

[HTML][HTML] Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan

YH Liu, CH Chen, SY Chen, YJ Lin, WL Liao… - Journal of biomedical …, 2010 - Springer
Background Idiopathic membranous nephropathy (IMN) is one of the most common forms of
autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether …