Anti-phospholipase A2 receptor antibody in membranous nephropathy

W Qin, LH Beck Jr, C Zeng, Z Chen, S Li… - Journal of the …, 2011 - journals.lww.com
The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic
membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is …

[HTML][HTML] High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese

M Thiri, K Honda, K Kashiwase, A Mabuchi, H Suzuki… - Scientific reports, 2016 - nature.com
Although recent studies showed anti-PLA2R antibody plays a crucial role in idiopathic
membranous nephropathy (IMN), detailed HLA mapping and interaction between the HLA …

Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy?

DJ Salant - Journal of the American Society of Nephrology, 2013 - journals.lww.com
Primary (or idiopathic) membranous nephropathy is an organ-specific autoimmune disease
in which circulating antibodies to a conformation-dependent epitope in the target antigen …

Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy

L Kao, V Lam, M Waldman, RJ Glassock… - Journal of the American …, 2015 - journals.lww.com
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Recent
clinical studies established that> 70% of patients with idiopathic (also called primary) MN …

MHC class II risk alleles and amino acid residues in idiopathic membranous nephropathy

Z Cui, L Xie, F Chen, Z Pei, L Zhang, Z Qu… - Journal of the …, 2017 - journals.lww.com
Epitopes of phospholipase A2 receptor (PLA2R), the target antigen in idiopathic
membranous nephropathy (iMN), must be presented by the HLA–encoded MHC class II …

Phospholipase A2 receptor 1 epitope spreading at baseline predicts reduced likelihood of remission of membranous nephropathy

B Seitz-Polski, H Debiec, A Rousseau… - Journal of the …, 2018 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous
nephropathy. Several PLA2R1 epitopes have been characterized, and a retrospective study …

Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy

HC Stanescu, M Arcos-Burgos, A Medlar… - … England Journal of …, 2011 - Mass Medical Soc
Background Idiopathic membranous nephropathy is a major cause of the nephrotic
syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic …

Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy

JM Hofstra, H Debiec, CD Short, T Pellé… - Journal of the …, 2012 - journals.lww.com
The phospholipase A 2 receptor (PLA 2 R) is the major target antigen in idiopathic
membranous nephropathy. The technique for measuring antibodies against PLA 2 R and …

PLA2R and membranous nephropathy: a 3 year prospective Australian study

PA Hill, JL McRae, KM Dwyer - Nephrology, 2016 - Wiley Online Library
Aim The phospholipase A2 receptor (PLA2R) is the major target antigen in idiopathic
membranous nephropathy (iMN). The aim of this prospective study was to determine the …

HLA-DRB1* 15: 01 and HLA-DRB3* 02: 02 in PLA2R-related membranous nephropathy

WB Le, JS Shi, T Zhang, L Liu, HZ Qin… - Journal of the …, 2017 - journals.lww.com
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele
involved remains unknown. To identify the HLA risk alleles associated with phospholipase …