Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch
M Fresquet, MP Lockhart-Cairns… - Proceedings of the …, 2022 - National Acad Sciences
Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy
P Jullien, B Seitz Polski, N Maillard… - Clinical kidney …, 2017 - academic.oup.com
Background: The diagnostic role of circulating anti-phospholipase A2 receptor antibodies
(anti-PLA2R Abs) is now well recognized in idiopathic membranous nephropathy (iMN) …
(anti-PLA2R Abs) is now well recognized in idiopathic membranous nephropathy (iMN) …
[HTML][HTML] Clinical and histological features of phospholipase A2 receptor-associated and thrombospondin type-I domain-containing 7A-associated idiopathic …
D Zhang, J Zou, C Zhang, W Zhang, F Lin… - … Medical Journal of …, 2018 - ncbi.nlm.nih.gov
Background M-type phospholipase A2 receptor (PLA2R) was identified as the major target
antigen in idiopathic membranous nephropathy (IMN). Another target antigen, namely …
antigen in idiopathic membranous nephropathy (IMN). Another target antigen, namely …
Diagnostic value of phospholipase A2 receptor in idiopathic membranous nephropathy: a systematic review and meta-analysis
SL Hu, D Wang, WJ Gou, QF Lei, TA Ma… - Journal of nephrology, 2014 - Springer
Background Detection of M-type phospholipase A 2 receptor (PLA 2 R) can be used in
serologic diagnosis of idiopathic membranous nephropathy (IMN), but there are limited data …
serologic diagnosis of idiopathic membranous nephropathy (IMN), but there are limited data …
[HTML][HTML] A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathyámimics podocyte injury in patients
C Meyer-Schwesinger, NM Tomas, S Dehde, L Seifert… - Kidney International, 2020 - Elsevier
The phospholipase A2 receptor 1 (PLA2R1) is the major autoantigen in patients suffering
from membranous nephropathy. To date, the lack of endogenous glomerular expression of …
from membranous nephropathy. To date, the lack of endogenous glomerular expression of …
Membranous nephropathy: not just a disease for adults
Membranous nephropathy (MN) is an immune complex-mediated cause of the nephrotic
syndrome that can occur in all age groups, from infants to the elderly. While systemic …
syndrome that can occur in all age groups, from infants to the elderly. While systemic …
Anti-phospholipase A2 receptor antibody as prognostic indicator in idiopathic membranous nephropathy
YG Kim, YW Choi, SY Kim, JY Moon, CG Ihm… - American journal of …, 2015 - karger.com
Background: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing
idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R …
idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R …
[HTML][HTML] Noninvasive diagnosis of primary membranous nephropathy using phospholipase A2 receptor antibodies
Kidney biopsy is the gold standard to diagnose membranous nephropathy (MN).
Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor …
Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor …
Management of patients with membranous nephropathy
JM Hofstra, JFM Wetzels - Nephrology Dialysis Transplantation, 2012 - academic.oup.com
Membranous nephropathy (MN) is the most common cause of the nephrotic syndrome in
Europe, with an incidence of 5–10/million/year in adults [1]. Although MN can occur …
Europe, with an incidence of 5–10/million/year in adults [1]. Although MN can occur …
Histopathologic effect of APOL1 risk alleles in PLA2R-associated membranous glomerulopathy
CP Larsen, ML Beggs, PD Walker, M Saeed… - American Journal of …, 2014 - ajkd.org
African Americans have long been known to have a higher incidence of kidney disease than
those of European or Asian ancestry and others without recent African ancestry. 1 This …
those of European or Asian ancestry and others without recent African ancestry. 1 This …