Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease

A Caporali, M Anwar, Y Devaux, R Katare… - Nature Reviews …, 2024 - nature.com
The adult heart is a complex, multicellular organ that is subjected to a series of regulatory
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …

[HTML][HTML] The noncoding-RNA landscape in cardiovascular health and disease

V Di Mauro, M Barandalla-Sobrados… - Non-coding RNA …, 2018 - Elsevier
The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in
the human body. Therefore any alteration in regulatory networks that orchestrate heart …

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

C Bär, S Chatterjee, I Falcão Pires… - Cardiovascular …, 2020 - academic.oup.com
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-
coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs …

[HTML][HTML] Non-coding RNAs: the “dark matter” of cardiovascular pathophysiology

C Iaconetti, C Gareri, A Polimeni, C Indolfi - International Journal of …, 2013 - mdpi.com
Large-scale analyses of mammalian transcriptomes have identified a significant number of
different RNA molecules that are not translated into protein. In fact, the use of new …

[HTML][HTML] Extracellular non-coding RNAs in cardiovascular diseases

Z Jiapaer, C Li, X Yang, L Sun, E Chatterjee, L Zhang… - Pharmaceutics, 2023 - mdpi.com
Cardiovascular diseases (CVDs) remain the world's leading cause of death despite the best
available healthcare and therapy. Emerging as a key mediator of intercellular and inter …

Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy

C Bär, S Chatterjee, T Thum - Circulation, 2016 - Am Heart Assoc
Vast parts of mammalian genomes encode for transcripts that are not further translated into
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …

Non-coding RNAs and ischemic cardiovascular diseases

T Smani, I Mayoral-Gonzalez, I Galeano-Otero… - Non-coding RNAs in …, 2020 - Springer
Abstract The Ischemic Heart Disease (IHD) is considered a clinical condition characterized
by myocardial ischemia causing an imbalance between myocardial blood supply and …

[HTML][HTML] Deciphering non-coding RNAs in cardiovascular health and disease

A Das, A Samidurai, FN Salloum - Frontiers in cardiovascular …, 2018 - frontiersin.org
After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs)
currently represent one of the newest frontiers in cardiovascular disease (CVD) since they …

Noncoding RNAs in cardiovascular diseases

P Gurha - Current opinion in cardiology, 2019 - journals.lww.com
Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as
novel targets for intervention in various cardiovascular disease. Future studies aimed at …

[HTML][HTML] Long non-coding RNAs: at the heart of cardiac dysfunction?

L Hobuß, C Bär, T Thum - Frontiers in physiology, 2019 - frontiersin.org
During the past decade numerous studies highlighted the importance of long non-coding
RNAs (lncRNAs) in orchestrating cardiovascular cell signaling. Classified only by a …