Long noncoding RNAs in organogenesis: making the difference
P Grote, BG Herrmann - Trends in Genetics, 2015 - cell.com
A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein
coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are …
coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are …
Comparative transcriptomics analyses across species, organs, and developmental stages reveal functionally constrained lncRNAs
F Darbellay, A Necsulea - Molecular biology and evolution, 2020 - academic.oup.com
The functionality of long noncoding RNAs (lncRNAs) is disputed. In general, lncRNAs are
under weak selective pressures, suggesting that the majority of lncRNAs may be …
under weak selective pressures, suggesting that the majority of lncRNAs may be …
lncRNAs in development and differentiation: from sequence motifs to functional characterization
F Constanty, A Shkumatava - Development, 2021 - journals.biologists.com
The number of long noncoding RNAs (lncRNAs) with characterized developmental and
cellular functions continues to increase, but our understanding of the molecular mechanisms …
cellular functions continues to increase, but our understanding of the molecular mechanisms …
The functions of long noncoding RNAs in development and stem cells
RBT Perry, I Ulitsky - Development, 2016 - journals.biologists.com
Eukaryotic genomes are pervasively transcribed, with tens of thousands of RNAs emanating
from uni-and bi-directional promoters and from active enhancers. In vertebrates, thousands …
from uni-and bi-directional promoters and from active enhancers. In vertebrates, thousands …
LncRNAs in vertebrates: advances and challenges
AC Mallory, A Shkumatava - Biochimie, 2015 - Elsevier
Beyond the handful of classic and well-characterized long noncoding RNAs (lncRNAs),
more recently, hundreds of thousands of lncRNAs have been identified in multiple species …
more recently, hundreds of thousands of lncRNAs have been identified in multiple species …
Non-coding RNA expression, function, and variation during Drosophila embryogenesis
Long non-coding RNAs (lncRNAs) can often function in the regulation of gene expression
during development; however, their generality as essential regulators in developmental …
during development; however, their generality as essential regulators in developmental …
Identification and functional analysis of long non-coding RNAs in mouse cleavage stage embryonic development based on single cell transcriptome data
K Zhang, K Huang, Y Luo, S Li - BMC genomics, 2014 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) regulate embryonic development
and cell fate decision in various ways, such as modulation of chromatin modification and …
and cell fate decision in various ways, such as modulation of chromatin modification and …
Evolution of genome-organizing long non-coding RNAs in metazoans
A Ramírez-Colmenero, K Oktaba… - Frontiers in …, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) have important regulatory functions across eukarya. It is
now clear that many of these functions are related to gene expression regulation through …
now clear that many of these functions are related to gene expression regulation through …
Mechanisms of long noncoding RNA function in development and disease
SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
Developmental dynamics of lncRNAs across mammalian organs and species
Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …
mammalian genomes, there has been limited systematic functional characterization of these …