Blood vessels are central to numerous vital processes during development, homeostasis
and disease. They arise from complex developmental processes that culminate in the …

The Notch signalling pathway is one of the main regulators of endothelial biology. In the last
20 years the critical function of Notch has been uncovered in the context of angiogenesis …

Angiogenesis, or the formation of new blood vessels from pre-existing ones, is essential to
establish the vascular circuit during embryonic development. During angiogenic sprouting …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

An emerging hallmark of the Notch signaling pathway is its nearly ubiquitous participation in
cell fate decisions that affect several tissues, including epithelial, neuronal, hematopoietic …

The Notch signaling pathway is a highly conserved pathway involved in cell fate
determination in embryonic development and also functions in the regulation of …

Notch signalling represents a key pathway essential for normal vascular development.
Recently, great attention has been focused on the implication of Notch pathway components …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

It has become increasingly clear that the Notch signaling pathway plays a critical role in the
development and homeostasis of the cardiovascular system. This notion has emerged from …

The Notch proteins encompass a family of transmembrane receptors that have been highly
conserved through evolution as mediators of cell fate, and are comprised of 4 members in …