Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Stringent control of the NF-κB and type I interferon signaling pathways is critical to effective
host immune responses, yet the molecular mechanisms that negatively regulate these …

NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization
domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating …

Innate immunity activates the corresponding immune response relying on multiple pattern
recognition receptors (PRRs) that includes pattern recognition receptors (PRRs), like NOD …

Members of the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR)
family are quickly emerging as critical regulators of innate and adaptive immune responses …

Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

The innate immune system is the first line of defense against microorganisms and is
conserved in plants and animals. The nucleotide-binding domain, leucine rich containing …