Autoinflammatory syndromes cause sterile inflammation in the absence of any signs of
autoimmune responses. Familial cold autoinflammatory syndrome (FCAS) is characterized …

Recent data have shown that nucleotide-binding domain leucine-rich repeat proteins
(NLRs), a class of innate immune receptors that respond to pathogen attack or cellular …

The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate
innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory …

Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity
is pivotal for optimal control of pathogens and avoidance of immunopathology. The human …

Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular proteins
involved in innate-driven inflammatory responses. The function of the family member NLR …

NOD-like receptor family pyrin domain containing 6 (NLRP6) is a novel NLR family member,
that shows high expression in the intestine and liver (in contrast to NLRP3 in myeloid cells) …

NLR (nucleotide-binding domain, leucine-rich repeat–containing) proteins have rapidly
emerged as central regulators of immunity and inflammation with demonstrated relevance to …

NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …

Proteins of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing family
recently gained attention as important components of the innate immune system. Although …

Unique members of the nucleotide-binding domain leucine-rich repeat (NLR) family have
been found to regulate intracellular signaling pathways initiated by other families of pattern …