Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Although the etiology of multiple sclerosis (MS) remains enigmatic, the role of T cells is
unquestionably central in this pathology. Immune cells respond to pathogens and danger …

Chronic inflammation is regarded as an impor-tant factor in cancer progression. In addition
to the immune surveillance function in the early stage of tumorigenesis, inflammation is also …

Stringent control of the type I interferon signaling pathway is important for maintaining host
immune responses and homeostasis, yet the molecular mechanisms responsible for its tight …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and the
pathogenesis remains unclear. Previous studies suggested that fibroblast-like synoviocytes …

NOD-like receptors (NLR) are a family of cytosolic pattern recognition receptors that include
many key drivers of innate immune responses. NLRP12 is an emerging member of the NLR …

The NLR (nucleotide-binding domain leucine-rich repeat containing) proteins serve as
regulators of inflammatory signaling pathways. NLRX1, a mitochondria-localized NLR …

The nucleotide-binding oligomerization and leucine-rich repeat receptor (NLR) protein
family consists of important immune sensors that form inflammasomes, a cytosolic multi …

Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has
been identified to play a central role in the pathological progression of certain …

The NLRP3 inflammasome is central to host defense and implicated in various inflammatory
diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation …