[HTML][HTML] New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium
The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
Inhibition of the non-Mevalonate Isoprenoid pathway by reverse Hydroxamate analogues of Fosmidomycin
C Lienau, S Konzuch, T Gräwert, B Illarionov… - Procedia …, 2015 - Elsevier
The non-mevalonate (methylerythritol phosphate, MEP) pathway for isoprenoid biosynthesis
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
Deciphering the role of IspD (2‑C‑methyl‑D‑erythritol 4‑phosphate cytidyltransferase) enzyme as a potential therapeutic drug target against Plasmodium vivax
Biosynthesis of isoprenoids (MEP Pathway) in apicoplast has an important role during the
erythrocytic stages of Plasmodium, as it is the sole pathway to provide the major isoprene …
erythrocytic stages of Plasmodium, as it is the sole pathway to provide the major isoprene …
[Retracted] Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum
has created the need for prediction of novel targets as well as leads derived from original …
has created the need for prediction of novel targets as well as leads derived from original …
The isoprenoid-precursor dependence of Plasmodium spp.
JY van der Meer, AKH Hirsch - Natural product reports, 2012 - pubs.rsc.org
Covering: up to March 2012 Due to the increase in resistance of Plasmodium spp. against
available antimalarials, there is a need for new, effective and innovative drugs. The non …
available antimalarials, there is a need for new, effective and innovative drugs. The non …
Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target
Abstract The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the
apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the …
apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the …
Apicoplast metabolism: Parasite's Achilles' heel
Malaria continues to impinge heavily on mankind, with five continents still under its clasp.
Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current …
Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current …
Isoprenoid biosynthesis of the apicoplast as drug target
J Wiesner, H Jomaa - Current drug targets, 2007 - ingentaconnect.com
In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-
independent 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP …
independent 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP …
Isoprenoid biosynthesis in Plasmodium falciparum
AM Guggisberg, RE Amthor, AR Odom - Eukaryotic cell, 2014 - Am Soc Microbiol
Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …
Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies
ZK Yao, PM Krai, EF Merino, ME Simpson… - Bioorganic & medicinal …, 2015 - Elsevier
Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …