Pharmacological inhibition of NOS activates ASK1/JNK pathway augmenting docetaxel-mediated apoptosis in triple-negative breast cancer

D Dávila-González, DS Choi, RR Rosato… - Clinical Cancer …, 2018 - AACR
Purpose: Chemoresistance in triple-negative breast cancer (TNBC) is associated with the
activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress …

[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer

H Kumar, NV Gupta, R Jain… - Journal of Advanced …, 2023 - Elsevier
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …

Challenges for triple negative breast cancer treatment: defeating heterogeneity and cancer stemness

R Mahmoud, P Ordóñez-Morán, C Allegrucci - Cancers, 2022 - mdpi.com
Simple Summary Triple Negative Breast Cancer represents a cancer type with an unmet
clinical need. This type of breast cancer presents the worse clinical outcome due to its …

Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens

N Srivastava, SS Usmani, R Subbarayan… - Frontiers in …, 2023 - frontiersin.org
Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC)
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …

Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies

GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …

Challenges and opportunities in developing targeted therapies for triple negative breast cancer

AG Chapdelaine, G Sun - Biomolecules, 2023 - mdpi.com
Triple negative breast cancer (TNBC) is a heterogeneous group of breast cancers
characterized by their lack of estrogen receptors, progesterone receptors, and the HER2 …

Triple-negative breast cancer: The progress of targeted therapies and future tendencies

C Damaskos, A Garmpi, K Nikolettos… - Anticancer …, 2019 - ar.iiarjournals.org
Triple-negative breast cancer (TNBC) is characterized by a lack of expression of estrogen
receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 …

Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies

A Lee, MBA Djamgoz - Cancer treatment reviews, 2018 - Elsevier
Triple negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
which lacks oestrogen receptors, progesterone receptors and HER2 amplification, thereby …

Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial

YZ Jiang, Y Liu, Y Xiao, X Hu, L Jiang, WJ Zuo, D Ma… - Cell research, 2021 - nature.com
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular
subtyping may result in improved diagnostic precision and targeted therapies. Our previous …

Triple negative breast cancer treatment options and limitations: future outlook

O Obidiro, G Battogtokh, EO Akala - Pharmaceutics, 2023 - mdpi.com
Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …