This study was carried out to investigate whether rosmarinic acid (RA) has antifibrotic effect
on experimental liver fibrosis in vitro and in vivo and its possible mechanism. Culture of …

Rosmarinic acid (RA), a compound found in several plant species, has beneficial properties,
including anti-inflammatory and antibacterial effects. We investigated the toxicity, anti …

Resveratrol, a phytoalexin found in grapes and red wines, has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

AIM: Silymarin is a potent antioxidant, antiinflammatory and anti-fibrogenic agent in the liver,
which is mediated by alteration of hepatic Kupffer cell function, lipid peroxidation, and …

Hepatic fibrosis is a wound-healing process caused by prolonged liver damage and often
occurs due to hepatic stellate cell activation in response to reactive oxygen species (ROS) …

Silymarin is an herbal product showing potential as protection against hepatic disorders. In
an attempt to develop the agent for the treatment of hepatic fibrosis, we screened the effects …

AIM: To explore the anti-fibrotic effect of a traditional Chinese medicine, compound rhodiola
sachalinensis A Bor on CCl 4-induced liver fibrosis in rats and its probable molecular …

Background Silymarin derived from the milk thistle plant “Silybum marianum” is composed of
four major flavonolignans. Clinical as well as experimental studies indicate hepatoprotective …

Background β-sitosterol is a cholesterol-like phytosterol, which widely distributed in the plant
kingdom. Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human …

Oxidative stress in liver injury is a major pathogenetic factor in progress of liver fibrosis.
Resveratrol, a representative antioxidant derived from grapes, has been reported to show …